Peripheral Artery Disease (PAD)

Posted on November 17, 2014

This study is designed to assess an investigatory medication’s affect on the leg artery structure and physical activity in patients with atherosclerotic peripheral artery disease and leg pain from walking.

If you are interested you should:

  • Be 18-80 years of age
  • Have pain or fatigue in any of your leg muscles
  • Be taking aspirin or undergoing statin therapy for at least 6 weeks

Peripheral Artery Disease Study using Stem Cells


Peripheral arterial disease (PAD) is a disease of the blood vessels in the limbs, most commonly the legs. PAD occurs when arteries become narrow or clogged, due to atherosclerosis. Atherosclerosis, or “hardening of the arteries”, is a gradual process in which cholesterol, fat, and scar tissue build up on the walls of the arteries and form a plaque. This plaque narrows and clogs the arteries, restricting normal blood flow, and can eventually cause pain in the affected limb. While many people have mild or no symptoms, if left untreated, PAD can lead to critical limb ischemia (CLI), a serious form of the disease.

CLI symptoms can increase in severity from rest pain, to ulcers, to gangrene, eventually requiring amputation in some patients.

If you are interested you should:

  • Be 21 years of age or older
  • Have been told by a doctor that you have severe blockage in the arteries of one or both of your lower legs
  • Have a negative urine pregnancy test prior to enrolling into the study if you are a woman of child-bearing potential

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